Gastric signet ring cell adenocarcinoma associated with Menetrier’s disease: a rare North African female case report

Abstract

Background Menetrier's disease is an uncommon disease characterized by diffuse hypertrophy of gastric mucosa and giant gastric rugae with an increased risk of gastric cancer. Only a few reports supporting its association with gastric cancer have been found.Material and methodsWe present the case of signet ring cell adenocarcinoma associated with Menetrier's disease. The patient is a 54-year-old Algerian female.ResultsA 54-year-old woman was admitted to our hospital with a history of anemia, anorexia, and 10 kg weight loss. During her hospitalization, the patient presented an extradural hematoma. A biopsy was performed, which revealed a bone metastasis of the carcinomatous process. Abdominal computed tomography demonstrated diffuse thickening of the gastric wall. A gastric biopsy specimen showed thickened gastric mucosa and cystic dilatation of glands compatible with Menetrier's disease and diffuse infiltration by signet ring cell adenocarcinoma. A total gastrectomy was performed.ConclusionA patient with signet ring cell adenocarcinoma associated with Menetrier's disease is reported in our case study.