Peer-Reviewed Article May 30, 2009
Isolation, characterization and antibacterial activity of alkaloid from Datura metel Linn leaves
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Published in: African Journal of Pharmacy and Pharmacology
Publisher: Academic Journals • Nigeria • 1996-0816
Abstract
A new antibacterial agent 51,71 dimethyl 61– hydroxy 31, phenyl 3 ii - amine i¢ - yne sitosterol 1 has been isolated from Datura metel leaves. The structure of 1 was established using 13C, 1H NMR, IR and MS spectroscopic data. Compound 1 displayed antibacterial activity against Staphylococcus aureus,Pseudomonas aeruginosa, Proteus mirabis, Solmonella typhi, Bacillus subtilisand Klebsiella pneumonia but could not inhibit Escherichia coli. This result supported the use of Datura metel in phytomedicine for the treatment of asthma, cough, burns and healing of wounds in Nigeria. Key words: Datura metel, sterol alkaloid, antibacterial agent, phytomedicine.