Effect of Ginger Extract Consumption on levels of blood Glucose, Lipid Profile and Kidney Functions in Alloxan Induced-Diabetic Rats.

Abstract

In recent years, ginger has become a subject ofinterest because of its beneficial effects on human health. The purpose of thepresent study was to investigate the effects of daily oral administration of gingerextract for 6 weeks on plasma glucose, lipid profile and kidney functions inalloxan-induced diabetic rats to show the ameliorating and partly curativeeffects in alloxan induced-diabetic rats (150 mg/kg i.p.(Intrapretonial). Rats (130-150gm)were divided into 4 groups; normal control rats, diabetic control rats,diabetic rats post-treated with ginger and diabetic rats pretreated with ginger.Ginger extract was administered orally for 6 weeks to post-treated and pre-treatedrats, and they were compared with the normal and diabetic groups, respectively.Plasma glucose was reduced significantly in both post-treated and pre-treatedgroups. The post-treatment with ginger extract reduced plasma cholesterol,triglyceride and LDL-cholesterol, but during the pre-treatment with gingerextract produced insignificant change only in plasma triglyceride level. The plasmaHDL-cholesterol was significantly increased in post-treated and pre-treatedgroups. The plasma creatinine, urea and uric acid levels were significantly reducedin post-treated group; also in pre-treated group, they were reduced but urealevel statistically did not change. It is concluded that the consumption of gingerproduced a significant hypoglycemic effect in diabetic rats. In addition, gingeris capable of improving hyperlipidemia and the impaired kidney functions in alloxan-induceddiabetic rats