Role of Hypochromia and Microcytosis in theprediction of iron deficiency anemia

Abstract

Objective: The present study aimed at assessing the role of hypochromia and microcytosis in the determination of iron storage state and early detection of iron deficiency anemia (IDA).Background: Anemia is defined as hemoglobin (Hb) concentration below the reference range (Hb level below 13 g/dl in men, 12 g/dl in women, and 11g/dl in pregnant women and preschool children). The assessment of hypochromia and microcytosis can help more prediction of (IDA). Patients and methods: This study included 60 patients with normal Hb levels with decreased Mean Corpuscular Volume (MCV) & Mean Corpuscular Hemoglobin (MCH) and 30 healthy subjects as a control group. All patients were subjected to history taking, clinical examinations, laboratory investigations such as Complete blood count (CBC), serum iron, serum ferritin (SF), total iron-binding capacity (TIBC), C -reactive protein (CRP) and Hb. Electrophoresis. Results: Mean MCV, MCH, Serum iron, SF, TIBC, CRP, and Hb. Electrophoresis had statistically significant difference between the two groups (p-value <0.0001). Conclusion: It indicates an early sign of (IDA).Abbreviations: IDA; iron deficiency anemia, Hb; hemoglobin, MCV; Mean CorpuscularVolume, MCH; Mean Corpuscular Hemoglobin, CBC; Complete blood count, SF; serum ferritin, TIBC; total iron-binding capacity and CRP; C - reactive protein.