Development of a UV-spectrophotometric method for the simultaneous determination of aspirin and paracetamol in tablets

Abstract

A specific, rapid and simple UV spectrophotometric method with good sensitivity was developed and validated for the simultaneous quantification of aspirin and paracetamol in standard solutions and tablets. The method employed solving of simultaneous equations based on the measurement of absorbance at two wavelengths, 265 and 257 nm, λ max for aspirin and paracetamol, respectively. The calibration curve was linear for both drugs in a concentration range of 2 to 64 µg/ml. It can be concluded from the results that present method for the simultaneous determination of aspirin and paracetamol in tablets is specific, rapid and simple with good sensitivity. This analytical method is also applicable in ordinary laboratories also. It can also be adopted for quality control tests for these drugs in tablets.   Key words: UV spectrophotometric method, aspirin, paracetamol, simultaneous determination.