Standard Oxytocin versus High Dose Oxytocin to Control Postpartum Hemorrhage in High-Risk Pregnancy during Elective Cesarean Section

Abstract

Background: Cesarean sections elevate the possibility of anemia, blood transfusions, hysterectomy, postpartum hemorrhage and maternal mortality. Effective hemorrhage management prior to and during a Cesarean section reduces maternal mortality and morbidity. Uterine atony frequently results in lethal obstetric hemorrhage. Oxytocin is commonly given following a Cesarean delivery to reduce postpartum bleeding. Objectives: Assessing blood loss following the administration of standard and high Oxytocin dosages during elective Cesarean sections and to contrast the efficacy of the higher Oxytocin dosage against the standard dose for controlling blood loss in high-risk pregnancies. Material and Methods: This investigation has been a randomized controlled trial with 38 females, evenly split into 2 groups: Group A were given normal oxytocin dosage of 10 IU of infusion following from the initial bolus of 10 IU (n=19) & Group B were given high-dose oxytocin of 30 IU infusion following the initial bolus of 10 IU (n=19), based on similar inclusion and exclusion criteria. The study was performed at Ahmed Galal Military hospital, Almaza Military hospital and Shoubra Health Insurance hospitals. Results: No statistically significant differences were seen between Group A & Group B concerning blood loss (p=0.694) and risk variables (p=0.199). Conclusion: Administering a higher preventative dosage infusion of oxytocin following a Cesarean section does not mitigate the risk of substantial obstetric hemorrhage, compared to the impact of a low preventive dosage of oxytocin. However, a larger study might be needed to establish the significance of any small difference in outcome parameters.