Evaluation of antibacterial properties of Chebulic myrobalan (fruit of Terminalia chebula Retz.) extracts against methicillin resistant Staphylococcus aureus and trimethoprim-sulphamethoxazole resistant uropathogenic Escherichia coli.

Abstract

The aim of this study was to evaluate the possible antibacterial potential of Chebulic myrobalan extracts (cold aqueous, hot aqueous and ethanol) against multi-drug resistant bacterial pathogens. For this purpose both clinical isolates (methicillin resistant Staphylococcus aureus and trimethoprim-sulphamethoxazole resistant uropathogenic Escherichia coli) and standard type control strains were tested in this study. Antibacterial potency of the extracts was tested by standard growth inhibitory assay methods. All the tested extracts showed to varying degrees of strain specific antibacterial potential against tested strains of which ethanol extract showed superior activity against E. coli and hot aqueous extract against S. aureus. Cold aqueous extract exhibited the least antibacterial activity against all the tested strains. These promising findings suggest to antibacterial activity of the plant material exhibited bioactive compounds against multi-drug resistant bacterial pathogens and serving them as an alternative antimicrobial agent against diseases caused by these organisms.   Key word: Chebulic myrobalan, MRSA, Escherichia coli, antibacterial activity.