Possible Effects of Aluminum Chloride Induced Toxicity on Hippocampus of Adult Male Albino Rats

Abstract

Background: Aluminum (Al) is a widely used heavy metal in different aspects of daily life such as food, cosmetics, food additives, tooth paste and many pharmaceutical products . Also, it is an accumulative potent neurotoxin involved in the progression of various cognitive disorders with the highest concentrations in the hippocampus. Excessive Al intake for long time causes neuroinflammation. Aim of the work: This work aims to study the possible effects of aluminum chloride induced toxicity on adult male albino rat hippocampal histological structure. Methods: sixteen rats (16 rats) were equally divided into two groups: Control group (C- group) and aluminum chloride (Al Cl3) group (given at a dose of 100mg/kg). Histological study was carried on. Results: aluminum chloride (Al Cl3) group showed variable marked changes in hippocampal histological structure. Conclusion: Aluminum chloride had an obvious deleterious effect on adult male albino rat hippocampus structure. Keywords: Aluminum chloride, hippocampus, rats.