Peer-Reviewed Article August 9, 2021
MONOSODIUM GLUTAMATE SAFETY, NEUROTOXICITY AND SOME RECENT STUDIES
Are you an author of this work?Link to your sovereign AfriScholar profile
Published in: Al-Azhar Journal of Pharmaceutical Sciences
Publisher: Al-Azhar University, Faculty of Pharmacy • Egypt • 1110-1644 • 2535-1958
Abstract
Monosodium glutamate (MSG) is a worldwide flavor enhancer. Despite controversy surrounding the safety of MSG, it is still consumed in large amounts. This review provides a better understanding of the molecular mechanism of MSG induced neurotoxicity including the different ways of glutamate regulation in brain and umami taste signaling pathway. In addition, this review summarizes the history of MSG discovery and synthesis, products and natural food containing MSG, details of MSG safety and toxicity with limited allowed amounts that can be used according to different organizations opinion. Finally, this review enumerates the different MSG studies in both animals and humans in the last 20 years.