Peer-Reviewed Article May 26, 2019
IS IT POSSIBLE FOR THE 2-[(4-CHLORO-PHENYL)-(3,5-DIMETHYLPYRAZOL-1-YL)-METHYL]-MALONIC ACID DIETHYL ESTER TO PRESENT A POTENTIAL CANDIDATE HIV-INTEGRASE INHIBITOR ON THE BASIS OF ITS O,N,O-LIGAND STRUCTURE
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Published in: Journal Marocain de Chimie Hétérocyclique
Publisher: Institut Marocain de l'Information Scientifique et Technique IMIST • Morocco • 2605-5996
Abstract
The titled new functionalized ligand of type 2-[(aryl)-(cycloaminilyl)-methyl]- malonic acid diethyl ester (4) is prepared in good yield through condensation of 3,5-dimethylpyrazole, with 2-arylidene-malonic acid diethyl esters 3. The structure of 4 was determined by spectral (IR, 1H NMR), elemental analyses and X-ray diffraction data. The molecular conformation shows two possible pockets ready to coordinate two metal atoms.