Hepatotoxic effects of low dose oral administration of monosodium glutamate in male albino rats

Abstract

The present study is aimed at investigating the potentials of low concentration administration of monosodium glutamate in inducing hepatotoxic effects in male albino rats. Thus, monosodium glutamate at a dose of 5 mg/kg of body weight was administered to adult male albino rats by oral intubation. Treatment was daily for 28 days. The monosodium glutamate treatment significantly (p decreased the serum alkaline phosphatase activity by 71.97% but increased (p monosodium glutamate at a low concentration (5 mg/kg of body weight) could be hepatotoxic without significant cholestasis or pathologies of the bone.